The Longevity Lab: Advanced Biomarkers That Predict Your Next 20 Years

Standard blood tests tell you if you're sick. Longevity biomarkers tell you if you're aging optimally—and predict your health trajectory for the next two decades. These cutting-edge markers can guide precise interventions to reverse biological aging before decline becomes irreversible.

(Please reach out to me if you are concerned about the over simplification of labs you might be receiving from your PCP. I'll help you advocate for what you really need and what really makes a difference to your health!)

Welcome to the future of predictive longevity medicine.

Beyond Basic Labs

Standard Physical = Reactive Medicine:

• Wait for disease to develop
• Treat symptoms after they appear
• One-size-fits-all reference ranges
• Limited predictive power

Longevity Labs = Predictive Medicine:

• Identify dysfunction before symptoms
• Predict future health trajectory
• Optimize for peak performance
• Personalized intervention guidance

The Epigenetic Age Revolution

DunedinPace Testing

• Measures your current pace of biological aging
• Predicts 20-year health trajectory
• Tracks intervention effectiveness
• Most advanced aging biomarker available

What Your Score Means:

• Pace = 1.0: Aging at expected rate
• Pace = 0.8: Aging 20% slower (biological advantage)
• Pace = 1.2: Aging 20% faster (intervention needed)

Case Example: Robert, 64, had DunedinPace of 1.3 (aging 30% faster). After 8 months of targeted interventions, his pace dropped to 0.85 (aging 15% slower). He literally reversed his aging trajectory.

The Inflammation Aging Panel

Beyond Basic CRP: Standard CRP misses specific inflammatory pathways driving aging.

Advanced Inflammatory Markers:

• IL-6: Predicts cardiovascular events and cognitive decline
• TNF-α: Indicates systemic inflammatory burden
• IL-1β: Neuroinflammation and brain aging marker
• Fibrinogen: Clotting and cardiovascular risk
• Homocysteine: Vascular aging and methylation status

Optimal Targets:

• IL-6: <1.8 pg/ml
• TNF-α: <8.1 pg/ml
• IL-1β: <1.0 pg/ml
• Fibrinogen: <350 mg/dl
• Homocysteine: <8 μmol/L

The Metabolic Flexibility Assessment

Standard Tests Miss Metabolic Aging:

• Fasting glucose (too late)
• HbA1c (average, not variability)
• Basic lipids (miss particle size)

Advanced Metabolic Markers:

• Fasting Insulin: Early insulin resistance (<5 μIU/ml optimal)
• HOMA-IR: Insulin sensitivity calculator (<1.0 optimal)
• Adiponectin: Fat cell health hormone (>10 μg/ml)
• Leptin: Satiety and metabolic health (<10 ng/ml)
• Advanced Lipid Particles: LDL particle number and size

The Cellular Energy Assessment

Mitochondrial Function Markers: Your cellular power plants determine your aging rate.

Key Biomarkers:

• CoQ10: Electron transport chain function
• Citrate: Energy cycle efficiency
• Succinate: Mitochondrial respiratory capacity
• Malate: Citric acid cycle function
• Lactate: Cellular energy efficiency

NutrEval Testing: Provides comprehensive assessment of:

• Energy metabolism pathways
• Mitochondrial function markers
• Cellular energy production efficiency
• Targeted intervention guidance

The Cardiovascular Aging Panel

Beyond Basic Cholesterol: Total and LDL cholesterol don't predict heart attacks in people over 50.

Advanced Cardiovascular Markers:

• ApoB: Actual atherogenic particle number
• **Lp(a): Genetic cardiovascular risk factor
• Small Dense LDL: Most dangerous particles
• LDL Particle Number: True cardiovascular risk
• CAC Score: Coronary artery calcium (arterial age)

Please reach out to me if you are concerned about the over simplification of labs you might be receiving from your PCP. I'll help you advocate for what you really need and what really makes a difference to your health!